Anti Inflammation Diet

... to physiological conditions such as inflammation, diet, the neuro atypical brain, gut... protein or a mild OTC anti inflammatory med has even a... headache meds can reduce brain inflammation associated with morning symptoms. Illness...

... carb, low fat, higher protein diet I hadn't had any issues... Canarian anti inflammatory remedy which I found helped my internal inflammation. Targets...

... aren’t we. My very ‘anti inflammatory’ OMS diet (developed for trying to... doesn’t fit all in the anti inflammatory area, and our bodies ... to find the OMS programe/diet and it’s stood me in ... happy that by using the diet to keep my inflammation as low as possible, it...

... on sleep quality, low-grade chronic inflammation, immuno-modulation, metabolic health, and ...exposure, gut lining, and some anti‑inflammatory effects; Trulacta would act... well‑controlled inflammation and immune activation, which fits your diet and lifestyle... (ABCA1/ABCG1), HDL remodeling, inflammation, etc.—pathways that, in other... plaque, and a very anti‑inflammatory diet, these RNA nuances are ...

Researchers at Tokyo University of Science have shown that certain plant compounds like menthol from mint, 1,8‑cineole from eucalyptus, and capsaicin from chili peppers, when combined in specific pairs, suppress inflammatory signals in immune cells hundreds of times more effectively than when used alone. The team tested these phytochemicals in mouse macrophages exposed to a bacterial trigger that mimics inflammation, and found that capsaicin alone had the strongest effect, but the real leap came when it was paired with menthol or 1,8‑cineole, raising anti‑inflammatory activity by roughly 10‑ to 100‑fold in the experimental setup. The mechanism hinges on how the compounds interact with different signaling pathways: menthol and 1,8‑cineole act through transient receptor potential (TRP) channels and calcium signaling, whereas capsaicin appears to work through a separate, non‑TRP route, and their combined activation amplifies the overall dampening of inflammatory markers. The authors explicitly note that the results are from cultured cells, and that animal and human trials are still needed to see whether these combinations actually translate into stronger effects at normal dietary doses or just in the lab environment. For Reddit, the discussion hook is less “miracle spice blend” and more: how plausible is it that real‑world seasoning choices can meaningfully influence low‑grade inflammation, given that most prior studies either used unrealistically high concentrations or focused on single compounds. The paper suggests that the benefit of plant‑rich diets may come less from picking one “super” phytochemical and more from the way multiple compounds reinforce each other, which ties nicely into broader debates about functional foods, supplements, and what, if anything, actually changes at typical eating levels. submitted by /u/InterstellarKinetics to r/InterstellarKinetics [link] [comments]

**The Core Issue** Chronic inflammation is a "silent killer" linked to serious conditions like heart disease, type 2 diabetes, and cancer. While many plants contain anti-inflammatory compounds, scientists have struggled to explain why they seem to work in traditional diets but often fail to show effects in lab tests unless used in massive, unrealistic doses. **The Finding** Researchers from the Tokyo University of Science discovered that combining specific compounds—specifically capsaicin (chili peppers) with menthol (mint) or 1,8-cineole (eucalyptus)—creates a massive synergistic effect. When these ingredients are paired, their ability to suppress inflammation in immune cells increases several hundred-fold compared to using any of them alone. **Why it Matters** This explains why "anti-inflammatory foods" actually work even at the low concentrations found in a normal meal. It’s not about one "superfood," but how different molecules work together to trigger multiple signaling pathways in the body simultaneously. **Limitations of Study** The research was conducted on murine (mouse) macrophages in a laboratory setting. While it provides a clear molecular framework, more research is needed in animal models and human clinical trials to confirm these exact results in a living body. **Interesting Statistics** The study found that the anti-inflammatory response was amplified by several hundred times when capsaicin was combined with menthol or eucalyptus compounds. **Useful Takeaways** Don't just stick to one spice. Combining ingredients like chili peppers and mint might provide a much more powerful health boost than eating them separately. This could lead to more effective "functional foods," seasonings, and supplements that require smaller doses for better results. **Link to Study** https://doi.org/10.3390/nu18030376 **TL;DR:** Scientists found that mixing chili pepper compounds with mint or eucalyptus creates a "synergy" that fights inflammation hundreds of times better than eating them individually. submitted by /u/Technical_savoir to r/microbiomenews [link] [comments]

hi this is my first time posting on here! i’m 19 and have been diagnosed with endo for about 2 years now but struggling with it for close to 7. recently my flares have been very frequent and really painful :(. i have the mirena iud so im not really experiencing menstruation but i still definitely have a cycle lol. i have an appointment with some specialists in late may to maybe talk about a laparoscopy. but until then i wanted to see what i can do to ease my discomfort. definitely curious about anti inflammation diets since i often flare after i eat. not sure if people find changing their diet to actually work though so would love feedback about that. honestly any tips would help ive been struggling bad these past few months :( submitted by /u/Traditional-Bend1771 to r/endometriosis [link] [comments]

There’s a silent force working against your body every day. It’s not dramatic like an injury or a fever. It’s slow, quiet, and hidden deep inside your tissues. This is chronic inflammation, and it’s one of the biggest reasons we age, get sick, and feel tired before our time. Unlike the helpful kind of inflammation that helps you heal, this one sticks around, harming your cells day after day. But here’s the good news: you can fight back, and doing so could extend your life in powerful ways. Scientists now call this slow-burning damage “inflammaging.” Over time, it wears down your body like rust eats away at metal. It speeds up wrinkles, brain fog, aches, and fatigue. It damages your DNA, shortens your telomeres (the protective ends of your chromosomes), and slowly turns healthy cells into sick ones. Left unchecked, it’s a major trigger for diseases like Alzheimer’s, heart disease, diabetes, and even cancer. But it doesn't have to be your future. You don’t have to be perfect to reduce chronic inflammation. You just need to make consistent changes. One of the most powerful tools is an anti-inflammatory diet. That means filling your plate with colorful, healing foods: fatty fish like sardines, berries, leafy greens, cruciferous vegetables, avocados, extra virgin olive oil, and spices like turmeric and ginger. At the same time, cut back on things that fan the flames, like sugar, processed foods, white bread, and refined oils. Movement is medicine. Regular exercise is one of the best ways to turn down inflammation. You don’t need to run marathons, just walking 30–45 minutes a day, doing strength training a few times a week, or dancing in your living room all count. It lowers stress hormones, balances blood sugar, and boosts your immune system. Speaking of stress. Chronic stress is inflammatory, too. It raises your cortisol, which triggers more damage to your cells. But there are simple ways to calm your system: deep breathing, meditation, journaling, or even just going for a walk in nature. Laughing, connecting with friends, and doing something creative also switch your body into repair mode. Sleep is when you heal. If you’re not getting enough rest, inflammation builds up fast. Aim for 7–9 hours of solid sleep. Keep your bedroom cool and dark, stick to a routine, and avoid screens an hour before bed. One good night’s sleep can lower your inflammation levels the very next day. Your gut is ground zero for inflammation. A healthy gut means a calmer, more balanced body. Eat plenty of fiber, add in fermented foods like yogurt, sauerkraut, and kimchi, and avoid overusing antibiotics. A quality probiotic can help too, along with gut-healing nutrients like collagen, L-glutamine, and zinc carnosine. If you need extra support, some anti-inflammatory supplements can help: omega-3 fish oil, curcumin (with black pepper), vitamin D, magnesium, quercetin, and resveratrol are great options. But always talk to a healthcare provider before starting anything new. And finally, never underestimate the power of human connection. Loneliness increases inflammation. Spend time with people who lift you up. Call a friend, join a group, or volunteer. Love, laughter, and purpose aren’t just emotional. They’re biological tools for healing and longevity. The truth is, you have the power to slow aging from the inside out. Chronic inflammation doesn’t have to control your future. By making small, smart choices each day, you can turn down the fire, protect your cells, and open the door to radical life extension. — Dr. Georgios Ioannou, Anti-Aging Scientist submitted by /u/GarifalliaPapa to r/immortalists [link] [comments]

I have had psoriasis for a while now, and I am starting to look into how diet might help manage inflammation without relying only on medications. Foods rich in omega-3s and antioxidants, like fish or berries, appear to reduce cytokine activity based on some research I came across. It has not eliminated my flares, but adjusting my meals has made them less frequent and intense. This approach seems to support the body's natural processes. Have you tried dietary changes for psoriasis, and what results have you seen? Sharing could help others find balanced ways to cope. submitted by /u/SeniorHeat221 to r/Psoriasis [link] [comments]

- I checked my cortisol levels Chronic stress can raise cortisol, which can lead to stubborn belly fat. I noticed that when I was undereating, overtraining, not sleeping well, or constantly going, my body held on to fat for safety. For me, this is where less became more. - I kept inflammation under control As estrogen declines, systemic inflammation can increase. What helped me was prioritizing strength training, following an anti-inflammatory diet, and getting good-quality sleep. - I focused on healing my metabolism I stopped cutting calories and started eating at maintenance or in a slight surplus to nourish my body and support my metabolism. I made sure I was eating enough protein and building muscle because muscle is a metabolic tool. submitted by /u/ConsciouslivwithALI to r/veganfitness [link] [comments]

I've lost 9lbs so far! I went sugar free and began eliminating gluten for an autoimmune issue. The problem is that for 3 days that diet has gone down the toilet. I tried keeping within as best I could but I've attended back to back celebrations and no access to anything truly anti inflammatory. One day was pasta, another was sweets and today was a a birthday for someone near and dear and we went to town at our local Mexican spot- rice, beans, chips, enchiladas 🙈 I am committed to resuming tomorrow but how bad did I just set myself back? I'm assuming my body will have some kind of reaction, probably bloating, but I really am sort of panicking over here. submitted by /u/Otherwise_Cloud2807 to r/loseit [link] [comments]

The backstory nobody saw coming - my dad's a corporate exec. High-stress job he'd had for 20+ years. His way of dealing? "A couple drinks to decompress." Totally normal, right? That's what we all thought. Except somewhere along the way, "a couple" turned into daily drinking. Wine with dinner became wine before dinner. Then wine during work calls. Then keeping a bottle in his home office. What aging actually looked like: 1) Face went from "sharp for his age" to puffy and bloated 2) Developed a belly seemingly overnight (dude used to have abs) 3) Skin texture changed - just looked... older, rougher 4) Sleep quality tanked, which made everything worse 5) Memory started slipping - repeating stories, forgetting conversations We're talking a span of maybe 3-4 years. The transformation was honestly jarring. And at 62, his doctor basically told him his liver was showing signs of damage and his "biological age" was testing closer to mid-70s. Mid-70s. That's when my mom finally connected the dots and realized this wasn't just "getting older" - this was self-inflicted aging. Turns out there's actual science behind this. I went down a rabbit hole reading about how chronic alcohol use accelerates cellular aging, screws with your hormones, destroys sleep quality (which is HUGE for aging), causes inflammation... basically fast-forwards the aging process. My mom finally staged an intervention. We found Rolling Hills recovery center in Chester NJ. Dad did outpatient program (so he could keep working, which was important for his ego tbh). And six months later the difference is wild. He's dropped 20 pounds. Face looks less puffy. Skin looks healthier. Energy's back. Most importantly, he looks his age again - which sounds bad, but compared to looking 15 years older? It's a win. We talk a lot about aging "gracefully" and anti-aging routines - skincare, exercise, diet, all that. But nobody wants to address the elephant in the room: how many of us are actively aging ourselves faster with our coping mechanisms? I'm in my 30s and I've definitely noticed I drink more than I used to. "Adulting is hard" jokes, wine culture, whatever. Watching my dad's transformation made me realize this shit catches up with you - and when it does, it's not subtle. So yeah. If you're reading this and thinking "I probably drink more than I should" - you're probably right. And it's not just about your liver or whatever. It's literally aging you faster. submitted by /u/twcosplays to r/Aging [link] [comments]

I’m 28 and have psoriatic arthritis. For a while, the biologic treatments worked really well — I honestly felt like I had my life back. But over the past year or two, things started to go downhill. The meds stopped working, and I was getting hit with extreme flares that were completely debilitating. It’s been tough trying to stay positive and function day to day while dealing with that level of pain and stiffness. So recently, in kind of a last-ditch effort to ease my symptoms, I decided to switch to a completely anti-inflammatory diet. I thought it would be way more extreme than it actually is — it’s mostly just cutting out seed oils, refined sugars, white carbs, and alcohol (especially beer, which was a big one for me). After about three to four weeks, the results have been incredible. I still have some joint pain across my lower and upper spine, hips, and left knee, but it’s so much more manageable now, and the inflammation feels like it’s gone completely. It might seem like a big lifestyle change, but honestly, it’s so worth it. I put it off for way too long — if you’re struggling like I was, it’s definitely something to consider. I also recommend therapy and speaking out, lightens the load. submitted by /u/dandunne to r/PsoriaticArthritis [link] [comments]

My psoriatic arthritis really started flaring up in late August and has continued to get worse, especially after I got a cold in early October. It’s in my finger nails really bad and itches and burns so bad!!!! The inflammation from being sick basically gave me asthma and I was prescribed an inhaler, a nebulizer and oral steroids. The steroids basically cleared everything up and I actually felt like myself again, but it all came back worse when the steroids were gone. I don’t know what to go but I can’t live like this, my back, shoulders and neck hurt so bad!!! I take so much ibuprofen it’s probably terrible for my stomach. Biologics are my last resort as I have a 9 year old and a 6 year old and I don’t think it’s a great idea to suppress my immune system when my kids are always bringing home germs. I cut out gluten over a year ago and it helped immensely at first, but my flair ups are out of control now. I eat very healthy and I’m as active as I can be with my chronic pain and stiff joints. Has anyone ever tried the anti inflammatory diet? Did it help? Would you suggest over biologics? Should I ask for more steroids and take them along with starting the anti inflammatory diet? submitted by /u/DollyDagger66 to r/PsoriaticArthritis [link] [comments]

My doctor says that I need to reduce inflammation. The doctor says that there are a variety things that could be causing my inflammation, such as lack of sleep and added stress, which I have definitely been suffering from. I am having more trouble with the recommendation to try an anti-inflammatory diet. The recommendations I’ve seen for an anti-inflammatory diet tend to be very vague. Some of it is clearly consistent with a ketogenic diet, such as avoiding refined carbohydrates. However, I have also seen recommendations that an anti-inflammatory diet should avoid red meat and saturated fat. I eat red meat one to two times per week and eat plenty of saturated fat. I am not very eager to give up red meat or to reduce my saturated fat. Moreover, because I had gastric sleeve surgery about three years ago, I have reduced stomach capacity and cannot eat a lot of volume. I need to prioritize protein, so some things I used to be able to eat easily, like bulky salads, I just don’t have the capacity for anymore. The most common diet recommended for people who want to reduce inflammation is the Mediterranean diet, but I don’t think that will work with my stomach volume restrictions. I’m looking for help. What anti-inflammatory diet practices have you been able to incorporate into your ketogenic diet? submitted by /u/heather80 to r/keto [link] [comments]

(This post ended up being pretty long. It’s a celebration, info about my journey and a rant at the end about others who invalidate our journey bc we used GLP1s) Ya’ll, I’m 50 lbs from my goal!!! 😭 From 320 to 170 and my goal is 120. Plus, I’m 1 lb away from a 29.9 bmi! I started at 56.7 bmi, which I think is class 3 obesity. 29.9 puts me in overweight. 🥹 I did not think back in May 2024 when I started this journey (at first with Saxenda then changed to Zep in Aug 2024), that I’d be 150 lbs smaller in a little over a year. If you are starting in the higher range like I did, don’t let anyone tell you that you can only lose a certain percentage with Zepbound or that your loss will slow down greatly after you reach a year in or a certain weight. I’ve been on 15 mg for 3 months. This last month, I’ve lost the most I ever have in one month, 15 lbs. I’ve lost 46.88% of my original body weight. I realize everyone is different and for some it doesn’t work or loss is slow. But don’t get discouraged if you are just starting out and have a lot to lose. As for diet, I eat anti-inflammatory. I have lipedema and I’ve seen huge improvements on my legs from cutting out foods that inflame me. The lipedema is definitely still there along with a lot of extra skin but my legs are loose and jiggly instead of swollen, full, tight and fibrotic. I can see some definition in my quads that I’ve never seen before. But I’m gluten and dairy free (except hard aged cheese thank goodness 😂), low oxalate, low processed and low sugar, no red meat and I watch my carb intake but I’m not keto. Like I don’t replace bread and pasta with a gluten free option. I just don’t eat it regularly. But if I do have a craving, I buy gluten free pasta and cook myself a small portion. I don’t deny something I want as long as I stay gluten and dairy free. They are non negotiable. I mostly eat chicken, turkey, tuna, salmon, shrimp, scallops, squash, zucchini, broccoli, brussel sprouts, and cauliflower. I only drink water, mostly Aldi sparking mineral water. I get 1 Sonic diet Dr Pepper a week with sugar free cherry syrup, vanilla and lime wedges. If artificial sweeteners didn’t give me headaches, I’d have one every day. My favorite treat is frozen cotton candy grapes. But they are out of season so I’ve got to find something else after I finish my last bag. As far as exercise, before I started my new job, I walked 3-4 miles 3 days a week. But the other days I was pretty sedentary. Now I’m getting about 10k steps everyday so even though I’m not walking those 4 miles, I’m sure it equals out bc I’m no longer sedentary with days I got under 1000 steps 😅. My lifting is still not a routine. I’d love for it to be. I just have to find a good schedule that works best between my job, family responsibilities etc. I feel like it’s the part of my life that I’m allowing excuses in right now. I’m not prioritizing lifting and my body shows it. So that’s my next move. Any advice on making exercise a routine, balancing it with life responsibilities, or even figuring out what to do is greatly appreciated. Right now, I have multiple collections on IG for different target areas and I save people’s content to the collections. That way it’s easy to refer to. Much love to everyone on this journey, no matter if you’re just starting Zepbound or compounded tirzepatide, somewhere along the journey or you’re in maintenance. The path we’ve chosen to get healthy, lose weight, lose inflammation (whatever your goal and reason is) is just as legit and valid as someone who does it without the meds. We all have different genetic makeup. Some need GLP1s as a tool to correct issues in our bodies. Do not let people make you feel less than or guilty for using it. It’s your body. I don’t guilt trip a person with depression for taking SSRIs. Can you imagine telling them it’s easy, just meditate and journal? I don’t guilt trip a diabetic for taking insulin. I don’t guilt trip someone with ADHD for taking a stimulant. We don’t tell them to treat it naturally. So I won’t feel guilty for taking Zepbound, greatly increasing my life expectancy and improving my quality of life! I can’t wait to update yall again when I reach my goal of 200 lbs lost. 🥰❤️ submitted by /u/AccomplishedEmu7751 to r/Zepbound [link] [comments]

To whomever originally shared this link on another post, I thank you. This diet WORKS. I've been stuck in a bad flare for 6 weeks, but it's been steadily getting better ever since I started this diet about a week ago. There are three phases and I'm currently in a mix of Phase 1 and 2, exploring what I can handle from the 2nd phase. It's worth trying, y'all! It has a lot to do with gut biome and good bacteria and creating that good environment for your insides that reduces inflammation. https://www.umassmed.edu/nutrition/ibd/ibdaid/ submitted by /u/Classic26 to r/UlcerativeColitis [link] [comments]

submitted by /u/mvea to r/psychology [link] [comments]

submitted by /u/mvea to r/science [link] [comments]

There’s a silent force working against your body every day. It’s not dramatic like an injury or a fever. It’s slow, quiet, and hidden deep inside your tissues. This is chronic inflammation, and it’s one of the biggest reasons we age, get sick, and feel tired before our time. Unlike the helpful kind of inflammation that helps you heal, this one sticks around, harming your cells day after day. But here’s the good news—you can fight back, and doing so could extend your life in powerful ways. Scientists now call this slow-burning damage “inflammaging.” Over time, it wears down your body like rust eats away at metal. It speeds up wrinkles, brain fog, aches, and fatigue. It damages your DNA, shortens your telomeres (the protective ends of your chromosomes), and slowly turns healthy cells into sick ones. Left unchecked, it’s a major trigger for diseases like Alzheimer’s, heart disease, diabetes, and even cancer. But it doesn't have to be your future. You don’t have to be perfect to reduce chronic inflammation—you just need to make consistent changes. One of the most powerful tools is an anti-inflammatory diet. That means filling your plate with colorful, healing foods: fatty fish like salmon, berries, leafy greens, avocados, olive oil, and spices like turmeric and ginger. At the same time, cut back on things that fan the flames, like sugar, processed foods, white bread, and refined oils. Movement is medicine. Regular exercise is one of the best ways to turn down inflammation. You don’t need to run marathons—just walking 30–45 minutes a day, doing strength training a few times a week, or dancing in your living room all count. It lowers stress hormones, balances blood sugar, and boosts your immune system. Speaking of stress—chronic stress is inflammatory, too. It raises your cortisol, which triggers more damage to your cells. But there are simple ways to calm your system: deep breathing, meditation, journaling, or even just going for a walk in nature. Laughing, connecting with friends, and doing something creative also switch your body into repair mode. Sleep is when you heal. If you’re not getting enough rest, inflammation builds up fast. Aim for 7–9 hours of solid sleep. Keep your bedroom cool and dark, stick to a routine, and avoid screens an hour before bed. One good night’s sleep can lower your inflammation levels the very next day. Your gut is ground zero for inflammation. A healthy gut means a calmer, more balanced body. Eat plenty of fiber, add in fermented foods like yogurt, sauerkraut, and kimchi, and avoid overusing antibiotics. A quality probiotic can help too, along with gut-healing nutrients like collagen, L-glutamine, and zinc carnosine. If you need extra support, some anti-inflammatory supplements can help: omega-3 fish oil, curcumin (with black pepper), vitamin D, magnesium, quercetin, and resveratrol are great options. But always talk to a healthcare provider before starting anything new. And finally, never underestimate the power of human connection. Loneliness increases inflammation. Spend time with people who lift you up. Call a friend, join a group, or volunteer. Love, laughter, and purpose aren’t just emotional—they’re biological tools for healing and longevity. The truth is, you have the power to slow aging from the inside out. Chronic inflammation doesn’t have to control your future. By making small, smart choices each day, you can turn down the fire, protect your cells, and open the door to radical life extension. submitted by /u/GarifalliaPapa to r/immortalists [link] [comments]

Had anybody tried an anti inflammatory diet and if so did it work? Honestly I'm kinda holistic and scared of new meds so I'm trying to make birth control a last resort. submitted by /u/sleepingugly5 to r/endometriosis [link] [comments]

For those who eat an anti-inflammatory diet that switched from the general American diet what benefits have you noticed? Any recipes or recommendations ? submitted by /u/FormalCourage2910 to r/nutrition [link] [comments]

This post is the culmination of over a decade of research, testing, and persistence in advancing KP treatments and our understanding of this condition. Like so many of you, I have met with countless dermatologists across the country and sunk significant money into trying to effectively treat this condition. I wholeheartedly believe that this theory and the treatments I have proposed are the most effective and up to date options for reducing the severity of Keratosis Pilaris. Keratosis Pilaris is not caused by keratin buildup in the skin. Keratin buildup around the follicle is one of the last symptoms to develop in a series of cascading symptoms. Hi everyone- my name is Devin Beaubien (u/Poem_KP) and I moderate the r/keratosis subreddit. I've been researching Keratosis Pilaris and trying to understand what the condition is, why I have it, and how I could improve my situation for well over a decade. I've been pushing harder than ever on this research since my son developed KP as a toddler that was much more severe than mine was at the same age. In these past 5 years I believe I’ve discovered and developed a highly effective treatment to target the underlying barrier defects and inflammation/redness of KP. This was done through extensive testing and research, first by myself in a home-based lab, and then through partnering with a commercial R&D lab that helped me to formalize what I had developed. This post will attempt to summarize my proposal on the pathology of KP, treatment options, and why KP is such a misunderstood skin condition. At the time of posting, I believe that this KP theory is the most comprehensive research article ever compiled on Keratosis Pilaris. In the simplest terms, Keratosis Pilaris is a very common skin condition that begins with a single underlying root cause. That root cause is located in the epithelial skin barrier around the hair follicle where the barrier has cellular “gaps” (for lack of a better term) that allow moisture to escape and bacteria and allergens to pass into the skin, triggering an immune response. This barrier abnormality occurs well before keratin begins forming in the follicle. There are multiple KP symptoms that build on top of one another. From my research they follow this pattern: Skin cells fail to secrete lipids during maturation Skin barrier around the follicle is compromised Inflammation develops Sebaceous glands shrink and atrophy Hair follicles become brittle and curled Keratin accumulates in the follicle (creating the bumps) When inflammation recedes from the follicle it leaves behind post inflammatory hyperpigmentation (PIH) Nearly all treatments for KP are attempting to improve the texture of KP by chemically exfoliating the keratin buildup in the follicle, but since they do not adequately address all of the barrier issues or sebaceous gland shrinkage that develop prior to this symptom, the best results that you can expect to achieve are going to be texture improvements. Applying glycolic acid, lactic acid, salicylic acid, urea, and/or retinol to a compromised skin barrier is not going to do much for improving redness and inflammation. In fact it may very well do the opposite. While moisturizing the skin will help soften and reduce some dryness around the follicles, it’s a losing battle if your skin is not producing enough sebum (skin oil) to moisturize and protect your follicles. This next part is going to be complicated and represents the bulk of my research on KP. What I cover here is delved into with much more depth in the article I linked at the beginning (and end) of this post. I theorize that the barrier issues we see in KP are the direct result of deficient IGF-1 (Insulin Growth Factor 1) levels in skin tissue, combined with genetic mutations of Insulin growth factor receptors and the underlying cellular signaling pathways that regulate how skin cells mature and differentiate as they move through the layers of the skin. Consider the following: Studies testing IGF-1 inhibition result in a disrupted epidermis that looks strikingly like the barrier disruption seen in KP: https://pmc.ncbi.nlm.nih.gov/articles/PMC1430337/ & https://pubmed.ncbi.nlm.nih.gov/25660180/ IGF-1 and its effects on skin cells directly regulate skin cell maturation as the cells travel through the skin. Deficiency in IGF-1 and/or mutations in Insulin receptors would directly affect the skin cell as it differentiates and secretes lipids during the formation of the skin barrier around the SC-SG interface, which is exactly where we see barrier issues appearing in KP. https://pmc.ncbi.nlm.nih.gov/articles/PMC1430337/ & https://pubmed.ncbi.nlm.nih.gov/25660180/ This study identified mutation of cellular pathways (triggered by IGF-1) resulting in the development of KP: https://pubmed.ncbi.nlm.nih.gov/21062266/ IGF-1 levels are lowest in children and steadily increase as you age into adulthood, correlating with how we see KP improve in some children as they age or "grow out of their KP": https://www.sciencedirect.com/science/article/abs/pii/S2451965018300334 IGF-1 levels raise while we sleep, with sleep being crucial to hormone production. This correlates with people reporting that their KP appears less severe in the mornings upon waking. https://pmc.ncbi.nlm.nih.gov/articles/PMC10160412/ IGF-1 levels decrease and sebaceous glands are atrophied when undergoing Isotretinoin (Accutane) treatment. This correlates with the numerous reports we’ve seen in r/keratosis of people experiencing increased severity of KP after taking Accutane. https://pubmed.ncbi.nlm.nih.gov/20128787/ IGF-1 levels are affected by pregnancy during increased estrogen production and additional hormonal factors. This correlates with reports of KP severity changes during and post pregnancy. https://pubmed.ncbi.nlm.nih.gov/17492948/ PCOS and other conditions that affect insulin resistance also correlate with increased likelihood of KP development. https://pubmed.ncbi.nlm.nih.gov/22374641/ Diets that contain high glycemic foods (rapidly digested carbohydrates) and milk proteins can effect insulin resistance, providing a potential link for some between diet and KP that so often is reported in r/keratosis Keratosis pilaris can result from Dupilumab for the treatment of bronchial asthma. IGF-2 stimulates the secretion of the Th2 cytokine interleukin (IL)-10 by 40-70%, while Dupilumab has been shown to inhibit the Th2 pathway. This reinforces the assertion that mutations in this cellular pathway and its signaling are direct causes in the pathology of KP: https://onlinelibrary.wiley.com/doi/full/10.1002/cia2.12172 KP prevalence correlates with obesity, which in turn correlates with insulin resistance: https://pubmed.ncbi.nlm.nih.gov/30043128/ IGF-1 is also responsible for the regulation of lipogenesis, which is thought to occur through IGF-1’s effects on 5α-Reductase and the enzymatic process responsible for converting testosterone into DHT, which stimulates sebocyte proliferation. IGF-1 effective regulates sebum production in the skin. https://academic.oup.com/endo/article-abstract/133/2/447/3035051 I could continue but at this point I think you are probably seeing the same patterns I see. IGF-1 is also responsible for inhibiting inflammation via stimulation of IL-10 production which I believe is very crucial for people suffering from KPRF, a subtype of KP affecting the face with visible redness and flushing of the cheeks. ( https://pubmed.ncbi.nlm.nih.gov/15277570/ ) So to summarize, IGF-1 and its related cellular pathways are connected directly or is one step removed from every symptom experienced by those with KP. Deficiency in IGF-1 and IR mutation also correlates with all of the events that are known to affect KP development and severity. So the big question is how do we improve IGF-1 bioavailability in skin tissue to prevent barrier issues from forming, thereby preventing KP symptoms? For this, I believe I have a very compelling answer. Here is my arm with severe KP before and after applying this treatment for stimulating IGF-1 production in my skin through a topical lotion I developed: My arm after 12 weeks of continued twice daily application of topical RK & Indirubin Initially in my research I was testing multiple compounds on my skin to determine their effectiveness on my KP. I finally settled on two specific compounds: Raspberry Ketone: The aromatic compound in red raspberries has been studied for topical application and has been shown to stimulate significant IGF-1 production in skin tissue through sensory neuron activation. https://pubmed.ncbi.nlm.nih.gov/18321745/ Indirubin (Indigo Naturalis): An anti inflammatory that reduces keratinocyte proliferation and cytokine production in the skin. https://pubmed.ncbi.nlm.nih.gov/31838180/ By combining these ingredients into a jojoba oil base (which is a plant extracted oil that is chemically similar to human sebum) I believe I have created the most effective skincare topical for regulating Keratosis Pilaris. This topical solution was also iterated on to balance pH and add the lowest effective concentration of lactic acid to help turn over skin cells without irritation, reducing pigmentation that has occurred due to post inflammatory hyperpigmentation. I have written about this extensively on my website/blog, initially I tried to copy over the entire article but there is a 40,000 character limit and I know that linking your own site or blog post is against community guidelines, but if you find this theory interesting or want to see more evidence, feel free to DM me or head over to r/keratosis where I've shared more info. I really believe that we can approach KP skincare through a different lens. Thanks for reading :) submitted by /u/Poem_KP to r/SkincareAddiction [link] [comments]

CW for discussion of fad dieting. Hi everyone! I recently went to my doctor for a routine visit and discussed some concerns I’ve had for a long time with her (I have chronic fatigue, muscle/join pain, basically just kind of always feel like I have the flu) and she ordered some tests. For context, she’s been a very good doctor to me and listens to me experience really well. She had several recommendations for my pain and discomfort and then mentioned I could try an anti-inflammatory diet and see if it helped any. As part of the diet, she mentioned cutting back on glucose, gluten and something else I can’t remember now, if I could find affordable options that I enjoyed. I am interested in seeing if there’s any evidence about certain diets and inflammation, and am hoping to keep it centered around what I can add or enjoyable substitutes rather than restricting myself for no reason. I’ve had doctors try to get me on fad diets and I don’t want to fall into that, regardless of how much I do trust my current PCP. Anyone have resources, recommendations, thoughts? submitted by /u/footnotegremlin to r/MaintenancePhase [link] [comments]

My anxiety went on for years without me realizing what it actually was. And after a few years of treating my body very poorly with bad diet, minor alcoholism and drugs - my world came crashing down (literally: I got a bad case of derealization). Basically my whole family is on SSRI's and anti-anxiety meds, but I refused to take any meds before I had tried to give it my ALL on fixing it naturally. And it worked. Fixing my anxiety became my full-time job, and I’m completely cured. I used to not be able to get out of the house, now I’m able to travel all over the world.I’m not saying this will work for everyone, but a lot of us don’t respond well to medication and therapy - and this worked for me. Here’s the step-by-step BREAK THE GLASS emergency toolkit habit stack I used: 1. Accepting my anxiety. Read Hope and Help for Your Nerves, by Dr Claire Weekes 2. Exposure therapy: Expose yourself to your worst fear, REGULARLY. For me this meant taking a crowded bus every single day, and then one day flying alone (TERRIFYING! But a major key in my journey) 3. Doing cold therapy and breath work: A lot of you have heard of Wim Hof. In my experience, it works. I feel super zen after a cold shower and some breath work exercises. 4. Exercising (almost) every single day. A lot of anxiety is excess adrenaline. Burn it off by getting your heart rate up. 5. Diet: Stop eating food that makes you feel like shit. Look up nutritional strategies for easing anxiety. 6. Organize your thoughts. Have a system for storing all your thoughts and to-do’s. Look up «Zen to Done» by Leo Babauta. 7. Journaling. Write a stream of consciousness of your negative thoughts every night before going to bed. Doing this makes it feel like the paper takes the burden off your shoulders. 8. Skipping on coffee (for a while). I stopped drinking coffee for 6 months and replaced it with tea. Coffee can create a lot of inflammation and adrenaline in your body, which is great for being productive (but not for your anxiety and sleep). 9. Sleep well. Get sunlight in your eyes as soon as you wake up (or light therapy), calm down 1-2 hours before bed and go to bed in a dark, chill room without any screens. If you struggle with sleep anxiety (like I did), read «The Sleep Book» by Dr Guy Meadows. That’s it! A lot of people have unintentionally self-inflicted anxiety caused by a poor lifestyle, and this is what turned my life around from saying «when I die, I will finally be able to rest» to my gf and now LOVING every single day and being super grateful for everything. Trust me, don’t kick it unless you’ve tried it for at least 4 months! submitted by /u/Gunhoo to r/LifeProTips [link] [comments]

submitted by /u/Lemon_La_Croix to r/coolguides [link] [comments]