Vitamin D3 5000 Iu

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CB, After a serious dental issue last year, my maxillofacial surgeon recommended vitamin D3 - I take the 5000 IU. I'm hoping it works and that it will help maintain the bone in my mouth.

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i’m thinking of buying Decode Age DAKE 5000 (Vitamin D3 5000 IU + K2 MK-7 100 mcg) and wanted to get some opinions before I order it. Has anyone here used Decode Age supplements, and are they generally considered a reliable brand in terms of quality and accurate dosing? Also, I don’t currently know my Vitamin D levels, so I’m wondering whether 5000 IU daily is too much for someone looking to support general health rather than treat a diagnosed deficiency. submitted by /u/nutsbrainup to r/Fitness_India [link] [comments]

Hi-Tech Pharmaceuticals Mega Vitamin D3 + K2 just landed. D3 + K2 is one of those wellness combos that shows up in a lot of daily routines, especially for people focused on: Bone health† Immune support† Calcium utilization† General long-term wellness† The basic idea is that Vitamin D3 helps support calcium absorption, while Vitamin K2 helps support proper calcium utilization in the body.† It’s not the flashiest supplement category, but foundational products like this are often the ones people stay most consistent with. Curious what people here think: Do you take D3 by itself, or do you prefer a D3 + K2 combo? And do you take Vitamin D year-round, or mostly during winter / low-sunlight months? Drop your routine below 👇 https://www.samedaysupplements.com/hi-tech-pharmaceuticals-mega-vitamin-d3-k2-120-tablets.html Why Shop With Us? Trusted Since 2007 Same Day Shipping on qualifying orders placed before 3 PM EST Quality, authentic products from brands you know and trust † Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This post is for informational purposes only and does not constitute medical advice. Always consult with your healthcare provider before starting any new supplement, especially if you have a medical condition or are taking medication. Individual results may vary. submitted by /u/SameDaySupplements to r/SameDaySupplements [link] [comments]

For bones and immune system: The vitamins D3 and K2 are a real power duo and support your bones together. D3, the 'sunshine vitamin', is also relevant for your immune system and the calcium level in your blood.* Practical long-term supply: Only 1 tablet every 5 days contains the high dose of 125 μg ... submitted by /u/CaroSchnapptZu to r/DealLiebe [link] [comments]

Vitamin D3 vegan: Our vitamin D3 + K2 tablets contain high-quality vegan vitamin D3, which is derived from lichen (instead of animal lanolin) – 100% vegan. With vitamin K2: Vitamin D3 has been optimally supplemented with vitamin K2. We use MK-7 in the all-trans form with vitamin K2. Vitamin K2 contr... submitted by /u/CaroSchnapptZu to r/DealLiebe [link] [comments]

Guys, my vitamin D level has stayed exactly the same for 2 months. I’ve been taking 5000 IU of D3 along with K2, Omega-3, and butter in the mornings. Could this be the reason for my constant extreme fatigue? submitted by /u/Affectionate_House73 to r/Supplements [link] [comments]

Hey everyone, ​I’ve been reading up on Vitamin D3 supplementation and came across several claims saying that higher doses (specifically around 5000 IU daily) can interfere with melatonin production and trigger insomnia. ​For those of you taking 5000 IU (or similar doses) daily, ​Have you ever noticed it affecting your sleep quality? submitted by /u/chucrutcito to r/Biohackers [link] [comments]

24M Florida, train 5x a week. Last April my T came back at 480 ng/dL which is technically "in range" but garbage for my age and I was tired of it. Spent the next 12 months getting monthly bloodwork while running every popular natural T booster I could justify alongside actual lifestyle changes. Ended this April at 870. The data on what actually moved the numbers vs what was a complete waste is honestly kinda damning for the supplement industry. Methodology fwiw. Monthly draws at LabCorp through Ulta Lab Tests, $45 each, fasted, between 7-9am, same morning of the month roughly. Tracked total T, free T, SHBG, E2, LH, FSH. ~$540 on draws for the year and easily the best money I spent the entire time. Ok so what actually worked. Sleep. By a mile the biggest variable in the whole dataset. Leproult & Van Cauter 2011 in JAMA had young guys sleep 5 hrs a night for a week and T dropped 10-15%, equivalent to like 15 years of aging in 7 nights. My data was almost embarrassingly consistent with this. Months where my Oura averaged under 6.5 hrs my T came back 60-100 ng/dL lower than my 7.5+ months. Every single time. You can do everything else right and bad sleep will undo it. Bodyfat. Went 18% to ~13% on a slow cut over 6 months. T went up about 150 ng/dL in that window alone. Mechanism is aromatization in adipose tissue, less fat = less T converting to E2. My E2 went from 36 to 22 pg/mL across the cut, free T went up disproportionately. If you're above 20% and your T is bad, you basically don't have a supplement question, you have a body comp question. Heavy compounds. Squats and deadlifts twice a week, 3-6 rep range. The acute T spike from a single lifting session is real but doesn't matter for your morning trough numbers, which is what your bloodwork captures. What mattered was strength progression over months. Once my deadlift was at 1.8x bw the T floor had clearly shifted up. Cutting alcohol on weeknights. Months where I hit 0 drinks Sun-Thurs ran measurably higher than months I had 2-3 weeknight beers. Not subtle. Partly sleep architecture damage, partly direct testicular effects. Didn't cut it entirely, kept Friday/Sat social, just stopped the casual weeknight thing. Now the supplements. Some did stuff, most didn't. Vitamin D3 5000 IU w/ K2 MK-7. My 25-OH D was 22 ng/mL at baseline despite living in Florida (I work indoors, sue me). Pilz et al. 2011 in Hormone and Metabolic Research gave overweight men 3,332 IU daily for a year and saw real total T increases, but only in vitamin D deficient guys. Follow-up by Lerchbaum 2017 in JCEM found basically nothing in men with already-normal D. So this only works if you're deficient. I was. T came up roughly 50 ng/dL across the months I got my D from 22 to 55. Cheap, easy, closest thing to a free win in the entire stack. Zinc 25mg, 4 days a week. Prasad's old work in Nutrition journal (1996 iirc) showed dietary zinc restriction in young men dropped T from like 39.9 to 10.6 nmol/L over 20 weeks, which is wild and most people haven't actually read it. Same logic as vitamin D, only matters if you're deficient or marginal. My RBC zinc was low normal. Modest 30-50 ng/dL bump after correcting. Don't megadose tho, chronic high-dose zinc above 50mg depletes copper and you dig a hole pretty fast. Ashwagandha KSM-66 600mg, during a 3 month rough patch at work. Wankhede 2015 in J Int Soc Sports Nutr ran 57 young guys on 600mg KSM-66 with resistance training for 8 weeks and saw ~15% T increase. Mine bumped maybe 40 ng/dL during the cycle. But. And this is the part I never see talked about on this sub. Around week 10 I started getting noticeable emotional flatness. Like things I should have been hyped about just felt muted. Cycled off, mood came back in maybe 3 weeks. It's real, I wasn't imagining it, and I remember reading it shows up in some of the smaller studies if you dig but I can't pull the cite right now. Anyway. I'd run it again for a finite stress period but it's not staying in my permanent stack. Probably the most underreported side effect in the whole adaptogen space. Boron 10mg, weekdays only. Naghii 2011 in J Trace Elem Med Biol gave 8 healthy guys 10mg boron daily for a week and saw 28% increase in free T and 39% drop in E2. n=8 is tiny so I didn't expect much. My free T did go up roughly 10% across two months I tested it with a small E2 drop. Cheap as dirt, no side effects, kept it. Ok now the part that's going to piss people off. Stuff that did literally nothing on my labs: Tongkat ali (LJ100), 400mg for 8 weeks, ran it twice. Maybe a 20 ng/dL bump, well within my month-to-month noise. The human data is mostly small studies in stressed or hypogonadal men, not healthy guys with normal-ish T. The hype on this sub vs the actual evidence is almost funny. Fadogia agrestis, 600mg for 6 weeks. Literally zero on every marker. The whole hype train is built on rat studies and there's real liver toxicity signal in those same rat studies that nobody on this sub seems to want to talk about. The Huberman bump put this stuff everywhere but the human evidence is essentially nonexistent. Not running it again. D-aspartic acid. The 2009 Topo paper got everyone excited, every follow-up in trained men since has been null. Mine matched. 12 weeks, nothing. Tribulus terrestris. Did nothing in 8 weeks. The few "positive" studies are in men with sexual dysfunction measuring libido, not healthy guys with bloodwork. It's been a marketing scam for like 25 years and people still buy it. Fenugreek 500mg. Some libido stuff maybe, no T change on labs. The "T increase" claims are usually free T measured after libido bumped, mechanism probably isn't actually androgenic. ZMA. Did nothing that my zinc and magnesium weren't already doing separately. It's just zinc + mag + B6 with a fancy name and a markup. Pine pollen, generic "T support" caps with proprietary blends, anything with no exact doses on the label. All of it. If a brand won't show you the dose of every ingredient it's hiding underdosing, full stop. The thing nobody on this sub wants to hear. Sleep, bodyfat, lifting heavy, alcohol restraint. That's 80% of natural T optimization. Full stop. Supplements are at most a 10-15% bump on top of that, and only the ones tied to actual nutrient deficiencies (D, zinc) reliably move anything. Ashwagandha during stress is real but the side effect tail is worse than people admit. Boron is cheap so why not. Everything else is mostly marketing wrapped around one underpowered study and a confident YouTuber. If you're under 35, sleeping 5 hrs, sitting at 22% bf, doing only cardio, and stacking 4 T boosters, you're optimizing the wrong layer of the system entirely. Fix the lifestyle and your numbers will move more in 6 months than any "natural booster" stack will move in 2 years. It's not even close. Honestly the most useful thing I did all year was just the monthly bloodwork itself. Without that data I would have credited 3 different supplements with effects that were actually just the body fat dropping or sleep finally getting consistent. You can't separate signal from placebo on this stuff without real numbers, period. Curious if anyone here has run a longer stretch on Tongkat at higher doses (600+) and seen real bloodwork movement, mine was flat at 400 both runs but the hype is persistent enough I wonder if dose actually matters more than duration here. Disclaimer: Formatted & spell-checked by ai, experience, research, & findings are entirely my own. submitted by /u/Timely_Ad8989 to r/Biohackers [link] [comments]

Hi everyone, Hi everyone, I’m looking for some insight. I haven’t had my period for about 2.5 years (post-menopause). I recently started taking Vitamin D3 (5000 IU) with K2 (100 mcg). After a few days, I noticed a very small amount of spotting—tiny discharge, partly brown and a little red. It only happened once and was very minimal. I stopped the supplement and had no spotting for a few days. Then I took it again yesterday, and the spotting happened again (still very little). Has anyone experienced something similar after taking Vitamin D3 + K2? Could it be related to the supplement, or is it more likely something else? I’m continuing to monitor it. Thanks in advance! submitted by /u/Significant_Way_9068 to r/Supplements [link] [comments]

Firstly I’d love to hear others testimonies. I didn’t want to make this post until I was fully healed (so im still healing but have extremely small symptoms after ejaculation), but my brain kept annoying me that people are suffering tell them what you found, if I wait a day more, someone could have missed this life saving information. My story: addicted to porn 13, tried quitting for years, got sicker, had a sort of rough family, mom would sometimes not cook food as punishment that really messed me up, at 18 I quit porn but had to leave university only did 1 semester and failed all courses (I was going crazy and POIS was hurting me a lot cause of nocturnal emissions). At 19 I quit pornography entirely, but my nocturnal emissions stayed, leaving me so sick, I could not eat etc… I got stomach issues, dry eyes and weird tastes, used to have cramps, loss of appetite, feeling extremely physically weak. it was easy to connect the dots since if I didn’t have the nocturnal emissions for 20 days I felt healthy enough to go to the park and in general healthy and motivated. Right now my symptoms have become quiet negligible after emissions. firstly I want to say, I actually have no need to ejaculate in the first place, my issue was I was stuck in a cycle of, nocturnal emissions and then becoming sick for the next 10-20 days, basically completely debilitated, my family helped me get through it. Heres the cure for a huge number of you, raise your vitamin D blood level MINIMUM to 46.6ng/l (USA) and for others countries 115nmol/L. Firstly you must go do a blood test and check your initial levels, it should be $30-$40, pretty cheap. Now to raise your Vitamin D blood level you must take a dose bigger than 5k, it really depends on your weight and activity (most of us sedentary for now). Don’t listen to the recommendation for around 2k or less, as I said at least 5000 IU of vitamin D3 drops! drops are better absorbed, and easy to take bigger doses. the vitamin D3 drops I take 3-4 from Walmart pretty pure ingredients, coconut oil and pure d3. Doctors found my Vitamin D level at 17nmol/L in USA that is like 6ng/ml, that is critically deficient and I won’t rage at the doctor now but doctors are not educated well it seems (especially standard family doctors or clinic doctors) on vitamin D, she told me take 2000 IU daily, I took that dose for around 1 year! and raised my level to only 57nmol/l or around 22ng/ml, that is still very low, there was no harm that when I I Italy found out my vitamin D is extremely low to take 10,000 IU d3, it’s passed now. But after that I basically got a single dose 200,000 IU D3 from an auntie, who came from Pakistan, in Canada you need to be prescribed big doses can’t get them (it is not dangerous, extremely hard to overdose on Vitamin D, like extremely extremely hard). Basically took the d3 200k ampoule and put it in milk and drank it, check after 2 weeks my blood levels at 128nmol/l or around 50ng/ml. I feel alot better, symptoms are disappearing had night falls and the symptom's I was able to brush away. it’s only been 2 weeks and my life is changing for the better, this is the best and most natural way to fix your issue. much love to you all. Don’t take 200,000 IU doses daily or anything like that, I took only a single dose and will take daily around 7,000 IU to 10,000 IU to maintain it (depends on your weight!). I’m 151lbs. I‘ll link a few videos explaining why the 600-800 IU doses recommended are so preposterous, but let me explain what Vitamin D is and how it works. Vitamin D, is actually just the sunshine vitamin, when a certain raise from the sunlight hits your skin (sunny day), your body is able to produce pre-Vitamin D, and then your body processes it (not tryna go into detail), at some point your body basically has Vitamin D3, this is not yet the active form, it is processed lastly by your kidneys to turn into its active form which is held by proteins. Doctors check 25 HydroxyVitamin D, which is basically one step before activated form. Your body needs all the forms though. Most doctors actually call Vitamin D a hormone not Vitamin because of how profoundly it effects your body and because it behaves like hormone especially it’s activated last form. Today people are at home or in buildings all day, it is common knowledge among doctors that Vitamin D deficiency is like an epidemic. and it’s making a lot of us sick, low mood depression, it’s linked to that too. How does this tie back to your POIS? Vitamin D controls immune modulation, turning on and off and not over reacting, majority of people with low Vitamin D develop allergy’s like peanut allergy, dust/pollen allergy’s, etc... Basically if you have low Vitamin D your immune system is tweaking. Majority of POIS as far as I know is allergy/ auto immune disorder, I’m just gonna cite studies so you can get the point. “Data from the HealthNuts study published in the Journal of Allergy and Clinical Immunologyindicates that infants with vitamin D deficiency face an 11.51 times higher risk of peanut allergy. This 2013 study, which evaluated 5,276 infants in Australia, found the association was specifically significant among children of Australian-born parents. For more details, visit PubMed.” 11 times, CAN YOU BELIEVE THAT cause I can! ”The VITAL study, a large-scale clinical trial published in The BMJ, found that adults taking 2,000 IU of Vitamin D3 daily had a 22% reductionin the rate of confirmed autoimmune diseases compared to those taking a placebo. The study, which followed over 25,000 participants for five years, suggests that Vitamin D helps regulate the immune system and may prevent the onset of conditions like rheumatoid arthritis and psoriasis, with the protective effects becoming even more significant after two years of consistent supplementation. You can view the full study summary and data on PubMed.” I just wanna mention they used 2000IU which is low and basically like nothing, which means the real percentage is way higher than 22% reduction in auto immune disorder development. now why do I call it preposterous that giving anything below 5,000 IU is way to low, well I’ll explain then link 2 doctor videos. We get Vitamim D from the sun, and hoenst that’s the best thing, if you think you can sun bath, then that will literally be better and good enough then taking any D3 oil drops, because it’s the natural way of your body. “Full-body exposure to peak midday sun until the skin begins to turn slightly pink—known as one Minimal Erythemal Dose (MED)—can trigger the production of 10,000 to 25,000 IU of Vitamin D3 in the skin. For a fair-skinned individual, this process occurs in as little as 15 to 30 minutes; however, wearing a shirt and shorts significantly reduces this output to approximately 1,000 to 3,000 IU because the clothing acts as a physical barrier to the UVB rays necessary for synthesis. According to research published by Dr. Michael Holick in the Journal of Investigative Medicine, the body naturally regulates this process, preventing toxicity by breaking down any excess vitamin D produced beyond these levels. You can read the full scholarly article on PubMed Central.” you don’t need to turn your skin pink haha, but it’s just cause we evolved to be outside, and it makes a big difference whether your Black, White or Asian/south Asian. As your genes are for that place, as a south asian born in Pakistan living in Canada, Im especially vulnerable because my genes and body expect heat and sun all day long (pakistan is very hot/sunny), so they require more raise to make the some amount of Vitamin D as an European. Doctor Vids Doctors Once Prescribed 300,000 IU of Vitamin D — Here’s What Happened video explaining the famous error on why it is horrendous to say 600-800 IU d3 is enough that the medical institutes still have not publicly changed. Vitamin D mistake Be careful with the comments saying they took massive doses for years, it depends on weight and gender, my sister only need daily 6,500 IU to maintain while I need 7,500 IU and I’m 151lbs light weight at 6,2. To raise your Vitmain D level initially I do recommend trying to get your hands on a big dose likely need doctor to prescribe, just a as a single boost dose then continue maintaince dose 5,000 IU and more, monitor blood levels. Now why do I reccomend 115nmol/l or 46.6ng/ml? I will explain, it’s because although, I believe the doctors that say going higher is safe, this is the most risk free level and must be the minimum. “A 2012 study found that traditional East African populations maintain an average vitamin D level of 115 nmol/L (46 ng/mL) due to consistent sun exposure, suggesting an evolutionary baseline for humans. These findings indicate a significant, natural divergence from typical levels found in modern Western populations. See the study Here.” This study basically took the average of 64 African men from tribes which spend their days outside, they quiet comically noted that these tribes men seek the shade during the very sunny hours since their is an abundance of sun. It is recommended you take magnesium, k2 and Vitamin A when you take Vitamin D3 to basically help boost the balance and help stabilize things faster. But you don’t need pills, Pumpkin seeds (papitas) are extremely rich in Magnesium, so a snack size pack of those, as long as you consume Dairy, Cheese, Yogurt, Milk, you will get enough k2, and Vitamin A rich foods are cantaloupe and sweet potatoe. Vitamin A is quiet important as when vitamin D is doing its thing, it needs Vitamin A to sort of pair with it. (you can research that, nothing complicated). Antihistamines, which reduce allergic reactions and some people take to improve POIS symptoms, Vitamin D controls the natural regulation of histamines in your body (preventing the allergic reaction before it can happen), so you don’t need to take any other drugs. (Theory of what happens for some people not everyone) Ejaculation --> Semen and natural cytokine increase --> Body's immunity has something messed up and triggers a severe reaction detecting either the semen or cytokine increase as a critical infection (Video explaining what your body does during sickness or immune system threat) --> Muscle weakness, brain fog, loss of appetite follow as the body begins to launch its full immune system attack (at nothing), muscles get drained of energy as the immune cells need energy and take it from there --> what is causing your immune system to be messed up? For me it was not enough Vitamin D (low blood levels below 115nmol/l or 46.6ng/ml) Vitamin D insufficiency is extremely common, that is why I'm notifying you of this. Note: 1. Not recommending mega dosing, I took 200,000 IU ONCE, just to boost. 2. I recommend you to figure out your maintenance dose (different for everyone) to maintain vitamin D3 levels above 115nmol/l or 46.6ng/ml by trying 4,000 IU to 10,000 IU daily and having blood tests checked. 3. You must check your blood levels for Vitamin D, that gives you a solid factual number to work with and keeps you safe, you want to find a maintenance dose that allows you to maintain minimum 115nmol/l or 46.6ng/ml. This is my opinion, experience and what helped me. submitted by /u/LaughingPlan3t to r/POIS [link] [comments]

https://preview.redd.it/4tk6mhlsmstg1.png?width=1783&format=png&auto=webp&s=d817a6514e9a5304739e76126de3dd38653e5474 This is what i got while taking 5000 IU a day, i decided that since I'm only at 49 to start doing 10000 IU´s a day (plus k2 and magnesium as well ofc), but i just wanted a second opinion if this is a good choice on my part or not submitted by /u/Monke_with_a_Stick to r/Supplements [link] [comments]

took me an embarrassingly long time to figure this out so figured i'd share. i was on 2000 IU daily for probably two years. label said 2000, my doctor said 2000, the RDA basically says 2000. tested my 25-OH D and came back at 28 ng/mL. my doctor said "that's sufficient, you're fine." and technically she was right, the official cutoff is 20 ng/mL, so 28 clears the bar. what nobody told me is that the 20 ng/mL threshold was established specifically for bone health. that's it. it was never meant to represent optimal levels for immune function, mood, testosterone, any of the other systems vitamin D is actually involved in. most of the functional medicine literature and a growing number of researchers treat 40 to 60 ng/mL as the real target for overall health outcomes. i was sitting at 28 convinced i was fine. problem two was timing. vitamin D is fat soluble. this is printed on every bottle and then completely ignored in terms of what it actually means. fat soluble means it needs dietary fat to absorb properly through the gut. one of the absorption studies found roughly 50% greater uptake when D3 was taken with a high-fat meal versus fasted. i was taking mine first thing in the morning with my other supplements, no food. so not only was my dose probably too low, i was absorbing maybe half of it anyway. problem three, K2. when D3 increases calcium absorption from the gut, K2 (specifically MK-7) is what directs that calcium toward bone instead of soft tissue. the two aren't just commonly stacked for marketing reasons, the mechanistic case for pairing them is solid. i wasn't taking K2 at all. so i switched. 5000 IU D3 with 100mcg K2 MK-7, taken with dinner which is my biggest meal. tested 90 days later and came back at 47 ng/mL. i've tested four more times since and been consistently in the 40 to 55 range. that single change, no lifestyle overhaul, nothing else different, moved my levels almost 20 points. just to confirm it wasn't placebo i actually ran a dumb experiment where i dropped back to 2000 IU for 8 weeks to see what happened. levels fell back to 34 ng/mL. went back up to 5000 IU, rebounded to 48 on the next test. so yeah, the dose was the issue the whole time. the thing i keep seeing is people say "i take vitamin D" like that's the end of the sentence. what dose, what form, when, with what, have you ever tested to confirm it's doing anything. those details are everything with a fat-soluble compound. most people's protocol is two years of swallowing a capsule that absorbs at half capacity and keeps their levels in a range that technically avoids deficiency but doesn't actually do much. test your 25-OH D if you haven't. it's cheap to add to a panel. get your levels, not a doctor's reassurance that you're probably fine. wrote a longer version of this with all my actual test results if you want the full breakdown, link's in my profile EDIT: if you're reading this later, the key points are: vitamin D3 absorption depends heavily on taking it with dietary fat, dosage is highly individual (2000 IU is often not enough for many people), and blood testing for 25-hydroxyvitamin D is the only way to confirm effectiveness. most guidelines define ≥20 ng/mL as “sufficient” for bone health, but many experts and studies suggest a broader optimal range closer to ~30–60 ng/mL depending on the outcome measured. taking vitamin D with a fat-containing meal can significantly improve absorption, and factors like body weight, timing, and co-nutrients (like vitamin K2 and magnesium) can influence results. submitted by /u/Timely_Ad8989 to r/Supplements [link] [comments]

Just bought this creatine from Costco, and the serving size also has %625dv (5000iu) of vitamin d3? isn’t vitamin d fat-soluble? Wouldn’t this cause vitamin d toxicity if taken daily? submitted by /u/sixfeetwunder to r/Supplements [link] [comments]

Today, I was reading how new studies recommend 5000 IU/day of Vitamin D3, there’s a doc (Berg?) even suggesting 10k UI/day. I am aware that taking D3 should be done with K2 (120mcg) and Magnesium like Glycinate. submitted by /u/r34dingwhite to r/PeterAttia [link] [comments]

TL;DR: Overwhelming scientific evidence from clinical trials, risk assessments, and long-term studies shows that even 10,000 IU/day of Vitamin D3 is safe for healthy adults and does not cause hypercalcemia. The widespread fear is based on outdated guidelines. Vitamin K2 is a great supplement for its own benefits, but you don't need it to "protect" you from a risk that doesn't realistically exist at this dose. [Edit: This is not an invitation to take vitamin D supplements, but a clarification to debunk the "Vitamin D hypercalcemia" scare in healthy adults.] Hey everyone, You've seen the comments. Any time someone mentions regularly taking 5,000 IU or 10,000 IU of Vitamin D, the warnings about "hypercalcemia" and the demands to "take it with K2 or else!" come rolling in. This fear is not supported by research. Let's cut through the noise and look at the most convincing studies. 1. Even EXTREME Doses Fail to Cause Hypercalcemia Let's start with the most dramatic evidence. A 2019 study published in The Journal of Steroid Biochemistry and Molecular Biology followed long-term hospitalized patients taking Vitamin D3 for up to seven years. The doses ranged from 5,000 IU/day all the way up to 50,000 IU/day. The result? "There have been no cases of vitamin D3 induced hypercalcemia or any adverse events attributable to vitamin D3 supplementation in any patient... In summary, long-term supplementation with vitamin D3 in doses ranging from 5000 to 50,000 IUs/day appears to be safe." (McCullough et al., 2019) If doses of 25,000 and 50,000 IU per day don't cause hypercalcemia, the idea that 10,000 IU is dangerous simply falls apart. Another study gave patients with statin intolerance 50,000 to 100,000 IU per week (averaging ~7,000 to ~14,000 IU per day) for up to a year. The results? "Serum vitamin D rarely exceeded 100 ng/mL, never reached toxic levels, and there were no significant change in serum calcium or eGFR [kidney function]." (Jetty et al., 2016) 2. The Evidence-Based Safe Upper Limit is 10,000 IU/day The old government limit of 2,000 IU is what started this fear, but it's long been superseded by better data. A formal risk assessment was conducted in 2007 by Hathcock et al. to establish a new Tolerable Upper Intake Level (UL) based on modern clinical trials. Their conclusion was clear and direct: "Collectively, the absence of toxicity in trials conducted in healthy adults that used vitamin D dose ≥250 µg/d (10 000 IU vitamin D3) supports the confident selection of this value as the UL." (Hathcock et al., 2007) This wasn't just an opinion—it was the result of a rigorous scientific process to define safety. The paper explicitly calls the old FNB limit "too restrictive" and "not based on current evidence." 3. The Myth of Vitamin K2 as a "Shield" Vitamin K2 is a fantastic nutrient. It helps direct calcium into your bones and may help prevent arterial calcification. It is absolutely a great nutrient for bone and cardiovascular health. However, the idea that you need it to protect you from Vitamin D-induced hypercalcemia is a solution in search of a problem. As the evidence shows, even a daily dose of 10,000 IU of Vitamin D does not cause an unsafe rise in blood calcium in the first place. Therefore, you don't need K2 to "protect" you from a risk that doesn't exist at this dose. Take K2 for its own excellent health benefits, not out of a misplaced fear that your Vitamin D supplement is dangerous without it. 4. So, Where Does REAL Toxicity Begin? True Vitamin D toxicity is exceptionally rare and is almost always the result of industrial accidents or massive, prolonged dosing errors far beyond what anyone would take supplementally. The Hathcock risk assessment notes that cases of toxicity involve "extraordinary intakes" that result in serum 25(OH)D levels climbing above 700-1600 nmol/L (280-640 ng/mL). For perspective, studies show that 10,000 IU/day typically gets people to around 150-200 nmol/L (60-80 ng/mL), which is considered by many experts to be an optimal physiological range (Vieth, 2006; Hathcock et al., 2007). Conclusion The science is clear and has been for over a decade: 10,000 IU/day of Vitamin D3 is a safe and well-studied dose for the general healthy adult population. The risk of hypercalcemia at this dose is negligible and not supported by modern clinical data. The official UL of 2,000-4,000 IU is outdated and overly cautious, hindering both research and public health. Vitamin K2 is a valuable supplement for bone and heart health, but it is not a "shield" against a toxicity that doesn't occur at these doses. So next time you see someone fearmongering about a 10,000 IU dose, you can be confident that their concerns, while well-intentioned, are not aligned with the current body of scientific evidence. Don't let the hypercalcemia meme cause unnecessary anxiety. (Important note: All of this applies to generally healthy adults. If you have conditions like sarcoidosis, primary hyperparathyroidism, or other issues related to calcium metabolism, consult your doctor before supplementing with vitamin D.) Sources Used for this Post: McCullough, P. J., Lehrer, D. S., & Amend, J. (2019). Daily oral dosing of vitamin D3 using 5000 TO 50,000 international units a day in long-term hospitalized patients: Insights from a seven year experience. The Journal of Steroid Biochemistry and Molecular Biology. Hathcock, J. N., Shao, A., Vieth, R., & Heaney, R. (2007). Risk assessment for vitamin D. American Journal of Clinical Nutrition. Jetty, V., Glueck, C. J., Wang, P., et al. (2016). Safety of 50,000-100,000 Units of Vitamin D3/Week in Vitamin D-Deficient, Hypercholesterolemic Patients with Reversible Statin Intolerance. North American Journal of Medical Sciences. Vieth, R. (2006). Critique of the considerations for establishing the tolerable upper intake level for vitamin D: critical need for revision upwards. The Journal of Nutrition. Papadimitriou, D. T. (2017). The Big Vitamin D Mistake. Journal of Preventive Medicine and Public Health. Further References (For those who want to dig deeper): These papers reinforce the post's message by showing that official recommendations (RDAs) are likely far too low, and that "safe" low doses are often not even effective for maintenance. Veugelers, P. J., & Ekwaru, J. P. (2014). A Statistical Error in the Estimation of the Recommended Dietary Allowance for Vitamin D. This is the groundbreaking paper that discovered a major statistical error in the Institute of Medicine's (IOM) calculation for the RDA, arguing the true RDA should be closer to 8,895 IU/day. Heaney, R. et al. (2015). Letter to Veugelers, P.J. and Ekwaru, J.P., A Statistical Error... This letter confirms the findings of the Veugelers paper using a different large dataset, calculating that an all-source intake of ~7,000 IU/day is needed to ensure sufficiency for 97.5% of the population. Sadat-Ali, M., et al. (2018). Maintenance Dose of Vitamin D: How Much Is Enough? This study found that a maintenance dose of 2,000 IU/day was not enough to keep patients sufficient after their deficiency was corrected, reinforcing that higher doses are often necessary even for maintenance. submitted by /u/TwoSongsPerDay to r/Supplements [link] [comments]

Hey everyone, I recently got my vitamin D levels checked, and they were on the lower side. I’ve seen recommendations for taking 5000 IU of vitamin D3 daily, but I’m not sure if it’s safe. Is this too much to take every day? Should I get advice from a doctor, or is this dosage generally fine for most people? I’d love to hear from anyone who’s been supplementing with vitamin D3. How much do you take, and has it helped with your energy levels, mood, or overall health? Thanks in advance! submitted by /u/Covelle1 to r/VitaminTalk [link] [comments]

Reminder to take vitamin D3 test if you have higher risk factor for deficiency (like me)!!!! So in January I was severely deficient in D and literally feeling like I was dying. and I have multiple risk factor for vitamin D3 deficiency (my medication affecting my Vitamin D3 metabolism, my dark skin, living in basement, chronic health condition, work from home, living in Canada etc), and my doctor told me to get more sun. So I was out in the sun 3 hours everyday in summer, (and I avoided using sunscreen) and I also started d taking 5'000 IU per day + K2 + magnesium. and in end of August my level was at the highest possible level @ 250nmol/L (reference range is 75-250nmol/L). And now just within 2 months, it seems like it has already gone down to 150nmol/L. Meaning it already gone down to 60% of my peak level. And right now my only source of D3 is my daily 5'000IU and I guess that amount is not enough. I probably need to up my dose to 10'000 IU. . . Edit: I'm a very skinny person, probably that is another reason too submitted by /u/nikkinoks to r/VitaminD [link] [comments]

So I had levels of 45, I know 50 is the threshold to reach according to some. I’ve always felt good from Vitamin D supplements so I took 5000 iu for 3 months, and even 10,000 for a couple days. My levels went from 45 to 44. Does anyone know what can cause this ? Why wouldn’t my levels go up? Should I take more ? submitted by /u/Professional_Win1535 to r/Supplements [link] [comments]

So I had levels of 45, I know 50 is the threshold to reach according to some. I’ve always felt good from Vitamin D supplements so I took 5000 iu for 3 months, and even 10,000 for a couple days. My levels went from 45 to 44. Does anyone know what can cause this ? Why wouldn’t my levels go up? Should I take more ? submitted by /u/Professional_Win1535 to r/Biohackers [link] [comments]

I've always avoided taking vitamin supplements because I didn't think I needed any. But I kept hearing about vitamin D and its numerous benefits, and since I don't get enough daily sun exposure, I thought I'd give this one a try. So I've been taking a vitamin D3 with K2 supplement for a few weeks now. Why the K2? Because these two vitamins work together in the body and vitamin K can reduce some of the harmful effects of a vitamin D overdose/toxicity. It is often advised that you should take vitamin K with D, and conveniently, many brands on the market have this combo in one supplement. What results did I experience? Well, it's hard to say for sure, but I did notice two changes that I think are a result of my supplementation with vitamins D and K: I feel a little more energetic and less lethargic. I wasn't expecting this, but I also noticed that my knee joints hurt less following certain physical activities. Regarding the second point, I've done a quick research and found out there is some scientific evidence suggesting that both vitamin D and vitamin K might be beneficial for joint pain (read more here and here). These are my recommendations for effective vitamin D supplements both men and women can take: Sports Research Sports Research is one of the best quality brands of vitamin D3 + K2 you can buy these days. It's a certified vegan vitamin D3 sourced from lichen, and it contains no junk fillers or additives. The softgels have coconut MCT oil and olive oil in them, which help with the absorption of D3 since it's a fat-soluble vitamin. Pros 2500/5000 IU per capsule Certified vegan vitamin D3 Third-party tested Contains coconut MCT oil for better absorption Clean product with no fillers Cons Expensive (like other vegan D3 supplements) Solaray Solaray has a good vitamin D3 + K2 formula with 5000 IU vitamin D3 per capsule, in addition to 50 mcg of K2 and a little bit of calcium and phosphorus. Pros 5000 IU per capsule Easy-to-swallow capsules Soy-free product Reasonable price Cons Doesn't contain oil to help with absorption NOW Foods NOW Foods is also a good brand many Reddit users trust. They make different vitamin D formulas, including D3 + K2 and D3 on its own in different strengths. Pros 1000/2000/5000/10000 IU per serving Easy-to-swallow softgels Very affordable brand Tested and made in the USA Cons Softgels contain gelatin (bovine) submitted by /u/neurovim to r/SupplementQuest [link] [comments]

In the last couple of weeks I've seen half a dozen or so people here mention that they're taking 5000 IU of D3. I'm wondering if I should try that as someone who lives in a colder climate and doesn't get much sunlight. But 5000 IU is above the upper limit of 4000 IU, so I'm nervous about going that high. What's the reasoning behind such a high dosage? submitted by /u/mrmczebra to r/Supplements [link] [comments]

submitted by /u/D-R-AZ to r/science [link] [comments]

I read on www.examine.com today that the safe limits of Vitamin D are only 4,000IU/day. This prompted me to double check the dosage on the ones I have been taking, and sure enough, I have been taking the 5,000IU daily for most of this year. Have I caused any permanent damage? Is complete cessation necessary or should I simply lower my dosage and continue on with life? Interestingly enough, when I went on amazon to order a lower dosage I noticed that 5,000IU was the top search result and seems to be a very common dosage of the remaining search results, this is how I probably ended up with these in the first place. Isn't this unsafe for the public? Thank you for your help and input. EDIT: Thank you guys so much for all of your input. I am going to switch to 2,000IU/day, start taking Vitamin K and get some new blood work. submitted by /u/PM_ME_HUGS_PLZ to r/Supplements [link] [comments]