Magnesium L Threonate

Does anyone know how useful magnesium L. Threonate might be with my RLS ...

Try just magnesium glycinate alone or try Magnesium taurate alone or Magnesium L‑threonate. Avoid malate and citrate. If your ferritin is low you are more likely to be sensitive to magnesium. Have you been tested as I suggested? If so what was it?

... better, anxiolytic and helps tolerance) Magnesium L Threonate (2000mg) (above) 1xWeekly (Monday) Boron...

... (3000mg) Taurine (3000mg) Theanine (400mg) Magnesium L Threonate (2000mg) 1xWeekly (Monday) Boron (10mg...

L citruline L carnitine Taurine alpha lipoid acid CLA ashwaganda D3 +k2 Turmeric Fish oil Lions Mane ZMA Magnesium threonate I’m forgetting some I’m sure.

....5g of Agmatine and 1000mg Magnesium L Threonate with each dose, I’ve been...

boutta get high as fuck from it 👁️ NMDA receptors? yeah , they're blocked . × think it's kicking in, yea.... boo-yah! submitted by /u/Most-Point856 to r/NooTopics [link] [comments]

Not theory. Not 10 tips for mental clarity. Previous post was removed but I made some edits to ensure it doesn't break any rules. These are the interventions that produced measurable changes in my cognition when I tested them one at a time with a 2 week baseline between each. I used Cambridge Brain Sciences daily at 7am to track working memory, reasoning, and verbal ability. Same time, same conditions, fasted. Here is what actually did something. Tier 1: The stuff that worked immediately and obviously CO2 management. Bought a $40 CO2 monitor. My bedroom was hitting 1,800ppm by 5am with the door closed. A Harvard study showed cognitive scores drop roughly 50% at 1,400ppm compared to 550ppm baseline. I cracked the window 2 inches. Never exceeded 700ppm again. Morning grogginess I had blamed on sleep quality for years was largely gone within 3 days. Cost: $40 once. Morning electrolytes before caffeine. 500ml water with 1/4 tsp salt and a squeeze of lemon within 20 minutes of waking. Before coffee. Before anything. Research shows 1 to 2% dehydration impairs working memory and you will not feel thirsty at that level. After 8 hours of sleeping you are dehydrated. Most people's first move is coffee which is a mild diuretic. You are draining an already dry system. This took 3 days to notice. Working memory scores up about 15% on testing mornings where I did this versus did not. Phone in another room during deep work. Ward et al. 2017 in JACR showed the mere presence of a smartphone on your desk reduces available cognitive capacity even face down and on silent. I tested this for 2 weeks phone on desk versus 2 weeks phone in kitchen. The difference in sustained focus was not subtle. Verbal fluency scores were consistently higher on phone-away days. Tier 2: The stuff that took 2 to 4 weeks but the effect was real Ferritin optimization. Mine was 22. Doctor said normal. It is not normal for brain function. Soppi 2018 showed cognitive symptoms at ferritin 15 to 30 that resolved above 50. I took iron bisglycinate 25mg every other day. Not daily. Research shows alternate day dosing has better fractional absorption because hepcidin peaks 24 hours after a dose and blocks absorption of the next one. At week 6 my ferritin was 58. Processing speed on cognitive testing improved noticeably around week 4. Vitamin D loading. Mine was 19 ng/mL in February. Supplemented 5,000 IU daily for 8 weeks then dropped to 3,000 IU maintenance. Retested at 52 ng/mL. The fog improvement was gradual. Not a single moment where it kicked in. More like I looked back at my scores after 6 weeks and realized the bad days had stopped. If you live above 35° latitude and have not tested your D levels you are probably deficient October through March. Magnesium glycinate 400mg before bed. Slutsky et al. published in Neuron 2010 showing magnesium enhances learning and memory. Serum magnesium is a garbage test because it only drops when you are severely depleted. Most people in western countries are sub clinically deficient. The sleep improvement was the first thing I noticed. Deeper sleep within 3 nights. The cognitive effect followed the better sleep by about a week. Do not use magnesium oxide. Bioavailability is terrible. Glycinate or threonate. Tier 3: The stuff people do not want to hear Caffeine elimination. I tapered from 400mg per day to zero over 8 weeks. Days 1 through 3 at each step down were rough. By week 10 at zero caffeine my baseline cognitive scores were higher than my best caffeinated scores. Caffeine does not add energy. It blocks adenosine receptors. Your brain compensates by building more receptors. Now you need caffeine to reach the baseline you would have had without it. I was borrowing from tomorrow every single day for 12 years. 30 minutes of cardio. Not negotiable. Not replaceable with supplements. A single session increases BDNF by 200 to 300%. One session. BDNF is the protein that drives neuroplasticity and repair. A year of regular walking increased hippocampal volume by 2% in clinical trials. That is 1 to 2 years of age related brain shrinkage reversed. Nothing in a capsule does this. Nothing. Cutting alcohol entirely. Not reducing. Cutting. A 2017 BMJ longitudinal study followed 550 people for 30 years. Even "moderate" drinkers at 14 to 21 units per week had significantly increased hippocampal atrophy. Ebrahim et al. showed alcohol destroys deep sleep architecture at any dose. I wore a sleep tracker. Zero deep sleep on drinking nights versus 80 to 90 minutes without. That was enough data. I stopped. Tier 4: The testing that found the actual root cause Full panel bloodwork. Not a CBC. Not a basic metabolic. This is what I asked for specifically: ferritin (not just hemoglobin), B12, folate, 25-OH vitamin D, RBC magnesium, TSH plus free T4 plus TPO antibodies, fasting insulin, HbA1c, CRP. Two things came back off that my DR never would have caught. The ferritin at 22 and the vitamin D at 19. Both technically in range. Both functionally impairing my brain. What did not work: Lion's mane. Took it for 8 weeks. No measurable change on cognitive testing. Maybe it works for some people. Did nothing for me. Alpha GPC. Same. 8 weeks. Nothing on testing. Noopept. Slight subjective feeling of clarity. Nothing on objective testing. Stopped. Modafinil. Worked acutely. Tolerance built within 2 weeks. Sleep quality tanked. Net negative after a month. What people do not want to accept: The boring stuff works. The exciting stuff mostly does not. Fixing your air, water, iron, vitamin D, magnesium, sleep, movement, and removing alcohol and excess caffeine will do more for your cognition than every nootropic stack on this sub combined. I know because I tested both. One at a time. With a cognitive testing baseline. The supplements are a rounding error on top of the fundamentals. Fix the fundamentals first or you are optimizing a system that is broken at the foundation. Studies referenced: Allen JG et al. CO2 and cognitive function scores. Environ Health Perspect. 2016. DOI: 10.1289/ehp.1510037 Armstrong LE et al. Mild dehydration affects mood in healthy young women. J Nutr. 2012. DOI: 10.3945/jn.111.142000 Ward AF et al. Brain Drain: smartphone presence reduces cognitive capacity. JACR. 2017. DOI: 10.1086/691462 - Soppi ET. Iron deficiency without anemia — a clinical challenge. Clin Case Rep. 2018;6(6):1082-1086. DOI: 10.1002/ccr3.1529 Slutsky I et al. Enhancement of learning and memory by elevating brain magnesium. Neuron. 2010. DOI: 10.1016/j.neuron.2009.12.026 Topiwala A et al. Moderate alcohol consumption as risk factor for adverse brain outcomes. BMJ. 2017. DOI: 10.1136/bmj.j2353 Ebrahim IO et al. Alcohol and sleep. Alcohol Clin Exp Res. 2013. DOI: 10.1111/acer.12006 submitted by /u/Sureokgo to r/getdisciplined [link] [comments]

Not theory. Not 10 tips for mental clarity. Previous post was removed but I made some edits to ensure it doesn't break any rules. These are the interventions that produced measurable changes in my cognition when I tested them one at a time with a 2 week baseline between each. I used Cambridge Brain Sciences daily at 7am to track working memory, reasoning, and verbal ability. Same time, same conditions, fasted. Here is what actually did something. Tier 1: The stuff that worked immediately and obviously CO2 management. Bought a $40 CO2 monitor. My bedroom was hitting 1,800ppm by 5am with the door closed. A Harvard study showed cognitive scores drop roughly 50% at 1,400ppm compared to 550ppm baseline. I cracked the window 2 inches. Never exceeded 700ppm again. Morning grogginess I had blamed on sleep quality for years was largely gone within 3 days. Cost: $40 once. Morning electrolytes before caffeine. 500ml water with 1/4 tsp salt and a squeeze of lemon within 20 minutes of waking. Before coffee. Before anything. Research shows 1 to 2% dehydration impairs working memory and you will not feel thirsty at that level. After 8 hours of sleeping you are dehydrated. Most people's first move is coffee which is a mild diuretic. You are draining an already dry system. This took 3 days to notice. Working memory scores up about 15% on testing mornings where I did this versus did not. Phone in another room during deep work. Ward et al. 2017 in JACR showed the mere presence of a smartphone on your desk reduces available cognitive capacity even face down and on silent. I tested this for 2 weeks phone on desk versus 2 weeks phone in kitchen. The difference in sustained focus was not subtle. Verbal fluency scores were consistently higher on phone-away days. Tier 2: The stuff that took 2 to 4 weeks but the effect was real Ferritin optimization. Mine was 22. Doctor said normal. It is not normal for brain function. Soppi 2018 showed cognitive symptoms at ferritin 15 to 30 that resolved above 50. I took iron bisglycinate 25mg every other day. Not daily. Research shows alternate day dosing has better fractional absorption because hepcidin peaks 24 hours after a dose and blocks absorption of the next one. At week 6 my ferritin was 58. Processing speed on cognitive testing improved noticeably around week 4. Vitamin D loading. Mine was 19 ng/mL in February. Supplemented 5,000 IU daily for 8 weeks then dropped to 3,000 IU maintenance. Retested at 52 ng/mL. The fog improvement was gradual. Not a single moment where it kicked in. More like I looked back at my scores after 6 weeks and realized the bad days had stopped. If you live above 35° latitude and have not tested your D levels you are probably deficient October through March. Magnesium glycinate 400mg before bed. Slutsky et al. published in Neuron 2010 showing magnesium enhances learning and memory. Serum magnesium is a garbage test because it only drops when you are severely depleted. Most people in western countries are sub clinically deficient. The sleep improvement was the first thing I noticed. Deeper sleep within 3 nights. The cognitive effect followed the better sleep by about a week. Do not use magnesium oxide. Bioavailability is terrible. Glycinate or threonate. Tier 3: The stuff people do not want to hear Caffeine elimination. I tapered from 400mg per day to zero over 8 weeks. Days 1 through 3 at each step down were rough. By week 10 at zero caffeine my baseline cognitive scores were higher than my best caffeinated scores. Caffeine does not add energy. It blocks adenosine receptors. Your brain compensates by building more receptors. Now you need caffeine to reach the baseline you would have had without it. I was borrowing from tomorrow every single day for 12 years. 30 minutes of cardio. Not negotiable. Not replaceable with supplements. A single session increases BDNF by 200 to 300%. One session. BDNF is the protein that drives neuroplasticity and repair. A year of regular walking increased hippocampal volume by 2% in clinical trials. That is 1 to 2 years of age related brain shrinkage reversed. Nothing in a capsule does this. Nothing. Cutting alcohol entirely. Not reducing. Cutting. A 2017 BMJ longitudinal study followed 550 people for 30 years. Even "moderate" drinkers at 14 to 21 units per week had significantly increased hippocampal atrophy. Ebrahim et al. showed alcohol destroys deep sleep architecture at any dose. I wore a sleep tracker. Zero deep sleep on drinking nights versus 80 to 90 minutes without. That was enough data. I stopped. Tier 4: The testing that found the actual root cause Full panel bloodwork. Not a CBC. Not a basic metabolic. This is what I asked for specifically: ferritin (not just hemoglobin), B12, folate, 25-OH vitamin D, RBC magnesium, TSH plus free T4 plus TPO antibodies, fasting insulin, HbA1c, CRP. Two things came back off that my DR never would have caught. The ferritin at 22 and the vitamin D at 19. Both technically in range. Both functionally impairing my brain. What did not work: Lion's mane. Took it for 8 weeks. No measurable change on cognitive testing. Maybe it works for some people. Did nothing for me. Alpha GPC. Same. 8 weeks. Nothing on testing. Noopept. Slight subjective feeling of clarity. Nothing on objective testing. Stopped. Modafinil. Worked acutely. Tolerance built within 2 weeks. Sleep quality tanked. Net negative after a month. What people do not want to accept: The boring stuff works. The exciting stuff mostly does not. Fixing your air, water, iron, vitamin D, magnesium, sleep, movement, and removing alcohol and excess caffeine will do more for your cognition than every nootropic stack on this sub combined. I know because I tested both. One at a time. With a cognitive testing baseline. The supplements are a rounding error on top of the fundamentals. Fix the fundamentals first or you are optimizing a system that is broken at the foundation. Studies referenced: Allen JG et al. CO2 and cognitive function scores. Environ Health Perspect. 2016. DOI: 10.1289/ehp.1510037 Armstrong LE et al. Mild dehydration affects mood in healthy young women. J Nutr. 2012. DOI: 10.3945/jn.111.142000 Ward AF et al. Brain Drain: smartphone presence reduces cognitive capacity. JACR. 2017. DOI: 10.1086/691462 - Soppi ET. Iron deficiency without anemia — a clinical challenge. Clin Case Rep. 2018;6(6):1082-1086. DOI: 10.1002/ccr3.1529 Slutsky I et al. Enhancement of learning and memory by elevating brain magnesium. Neuron. 2010. DOI: 10.1016/j.neuron.2009.12.026 Topiwala A et al. Moderate alcohol consumption as risk factor for adverse brain outcomes. BMJ. 2017. DOI: 10.1136/bmj.j2353 Ebrahim IO et al. Alcohol and sleep. Alcohol Clin Exp Res. 2013. DOI: 10.1111/acer.12006 submitted by /u/Sureokgo to r/selfimprovement [link] [comments]

Not theory. Not 10 tips for mental clarity. These are the interventions that produced measurable changes in my cognition when I tested them one at a time with a 2 week baseline between each. I used Cambridge Brain Sciences daily at 7am to track working memory, reasoning, and verbal ability. Same time, same conditions, fasted. Here is what actually did something. Tier 1: The stuff that worked immediately and obviously CO2 management. Bought a $40 CO2 monitor. My bedroom was hitting 1,800ppm by 5am with the door closed. A Harvard study showed cognitive scores drop roughly 50% at 1,400ppm compared to 550ppm baseline. I cracked the window 2 inches. Never exceeded 700ppm again. Morning grogginess I had blamed on sleep quality for years was largely gone within 3 days. Cost: $40 once. Morning electrolytes before caffeine. 500ml water with 1/4 tsp salt and a squeeze of lemon within 20 minutes of waking. Before coffee. Before anything. Research shows 1 to 2% dehydration impairs working memory and you will not feel thirsty at that level. After 8 hours of sleeping you are dehydrated. Most people's first move is coffee which is a mild diuretic. You are draining an already dry system. This took 3 days to notice. Working memory scores up about 15% on testing mornings where I did this versus did not. Phone in another room during deep work. Ward et al. 2017 in JACR showed the mere presence of a smartphone on your desk reduces available cognitive capacity even face down and on silent. I tested this for 2 weeks phone on desk versus 2 weeks phone in kitchen. The difference in sustained focus was not subtle. Verbal fluency scores were consistently higher on phone-away days. Tier 2: The stuff that took 2 to 4 weeks but the effect was real Ferritin optimization. Mine was 22. Doctor said normal. It is not normal for brain function. Soppi 2018 showed cognitive symptoms at ferritin 15 to 30 that resolved above 50. I took iron bisglycinate 25mg every other day. Not daily. Research shows alternate day dosing has better fractional absorption because hepcidin peaks 24 hours after a dose and blocks absorption of the next one. At week 6 my ferritin was 58. Processing speed on cognitive testing improved noticeably around week 4. Vitamin D loading. Mine was 19 ng/mL in February. Supplemented 5,000 IU daily for 8 weeks then dropped to 3,000 IU maintenance. Retested at 52 ng/mL. The fog improvement was gradual. Not a single moment where it kicked in. More like I looked back at my scores after 6 weeks and realized the bad days had stopped. If you live above 35° latitude and have not tested your D levels you are probably deficient October through March. Magnesium glycinate 400mg before bed. Slutsky et al. published in Neuron 2010 showing magnesium enhances learning and memory. Serum magnesium is a garbage test because it only drops when you are severely depleted. Most people in western countries are sub clinically deficient. The sleep improvement was the first thing I noticed. Deeper sleep within 3 nights. The cognitive effect followed the better sleep by about a week. Do not use magnesium oxide. Bioavailability is terrible. Glycinate or threonate. Tier 3: The stuff people do not want to hear Caffeine elimination. I tapered from 400mg per day to zero over 8 weeks. Days 1 through 3 at each step down were rough. By week 10 at zero caffeine my baseline cognitive scores were higher than my best caffeinated scores. Caffeine does not add energy. It blocks adenosine receptors. Your brain compensates by building more receptors. Now you need caffeine to reach the baseline you would have had without it. I was borrowing from tomorrow every single day for 12 years. 30 minutes of cardio. Not negotiable. Not replaceable with supplements. A single session increases BDNF by 200 to 300%. One session. BDNF is the protein that drives neuroplasticity and repair. A year of regular walking increased hippocampal volume by 2% in clinical trials. That is 1 to 2 years of age related brain shrinkage reversed. Nothing in a capsule does this. Nothing. Cutting alcohol entirely. Not reducing. Cutting. A 2017 BMJ longitudinal study followed 550 people for 30 years. Even "moderate" drinkers at 14 to 21 units per week had significantly increased hippocampal atrophy. Ebrahim et al. showed alcohol destroys deep sleep architecture at any dose. I wore a sleep tracker. Zero deep sleep on drinking nights versus 80 to 90 minutes without. That was enough data. I stopped. Tier 4: The testing that found the actual root cause Full panel bloodwork. Not a CBC. Not a basic metabolic. This is what I asked for specifically: ferritin (not just hemoglobin), B12, folate, 25-OH vitamin D, RBC magnesium, TSH plus free T4 plus TPO antibodies, fasting insulin, HbA1c, CRP. Two things came back off that my DR never would have caught. The ferritin at 22 and the vitamin D at 19. Both technically in range. Both functionally impairing my brain. What did not work: Lion's mane. Took it for 8 weeks. No measurable change on cognitive testing. Maybe it works for some people. Did nothing for me. Alpha GPC. Same. 8 weeks. Nothing on testing. Noopept. Slight subjective feeling of clarity. Nothing on objective testing. Stopped. Modafinil. Worked acutely. Tolerance built within 2 weeks. Sleep quality tanked. Net negative after a month. The takeaway nobody wants to accept: The boring stuff works. The exciting stuff mostly does not. Fixing your air, water, iron, vitamin D, magnesium, sleep, movement, and removing alcohol and excess caffeine will do more for your cognition than every nootropic stack on this sub combined. I know because I tested both. One at a time. With a cognitive testing baseline. The supplements are a rounding error on top of the fundamentals. Fix the fundamentals first or you are optimizing a system that is broken at the foundation. Studies referenced: Allen JG et al. CO2 and cognitive function scores. Environ Health Perspect. 2016. DOI: 10.1289/ehp.1510037 Armstrong LE et al. Mild dehydration affects mood in healthy young women. J Nutr. 2012. DOI: 10.3945/jn.111.142000 Ward AF et al. Brain Drain: smartphone presence reduces cognitive capacity. JACR. 2017. DOI: 10.1086/691462 - Soppi ET. Iron deficiency without anemia — a clinical challenge. Clin Case Rep. 2018;6(6):1082-1086. DOI: 10.1002/ccr3.1529 Slutsky I et al. Enhancement of learning and memory by elevating brain magnesium. Neuron. 2010. DOI: 10.1016/j.neuron.2009.12.026 Topiwala A et al. Moderate alcohol consumption as risk factor for adverse brain outcomes. BMJ. 2017. DOI: 10.1136/bmj.j2353 Ebrahim IO et al. Alcohol and sleep. Alcohol Clin Exp Res. 2013. DOI: 10.1111/acer.12006 Brain fog is kinda my thing so if you want to know more feel free to follow my profile and my r/whatisbrainfog subreddit where I will be releasing a site dedicated to it. submitted by /u/Sureokgo to r/HubermanLab [link] [comments]

Not theory. Not 10 tips for mental clarity. These are the interventions that produced measurable changes in my cognition when I tested them one at a time with a 2 week baseline between each. I used Cambridge Brain Sciences daily at 7am to track working memory, reasoning, and verbal ability. Same time, same conditions, fasted. Here is what actually did something. Tier 1: The stuff that worked immediately and obviously CO2 management. Bought a $40 CO2 monitor. My bedroom was hitting 1,800ppm by 5am with the door closed. A Harvard study showed cognitive scores drop roughly 50% at 1,400ppm compared to 550ppm baseline. I cracked the window 2 inches. Never exceeded 700ppm again. Morning grogginess I had blamed on sleep quality for years was largely gone within 3 days. Cost: $40 once. Morning electrolytes before caffeine. 500ml water with 1/4 tsp salt and a squeeze of lemon within 20 minutes of waking. Before coffee. Before anything. Research shows 1 to 2% dehydration impairs working memory and you will not feel thirsty at that level. After 8 hours of sleeping you are dehydrated. Most people's first move is coffee which is a mild diuretic. You are draining an already dry system. This took 3 days to notice. Working memory scores up about 15% on testing mornings where I did this versus did not. Phone in another room during deep work. Ward et al. 2017 in JACR showed the mere presence of a smartphone on your desk reduces available cognitive capacity even face down and on silent. I tested this for 2 weeks phone on desk versus 2 weeks phone in kitchen. The difference in sustained focus was not subtle. Verbal fluency scores were consistently higher on phone-away days. Tier 2: The stuff that took 2 to 4 weeks but the effect was real Ferritin optimization. Mine was 22. Doctor said normal. It is not normal for brain function. Soppi 2018 showed cognitive symptoms at ferritin 15 to 30 that resolved above 50. I took iron bisglycinate 25mg every other day. Not daily. Research shows alternate day dosing has better fractional absorption because hepcidin peaks 24 hours after a dose and blocks absorption of the next one. At week 6 my ferritin was 58. Processing speed on cognitive testing improved noticeably around week 4. Vitamin D loading. Mine was 19 ng/mL in February. Supplemented 5,000 IU daily for 8 weeks then dropped to 3,000 IU maintenance. Retested at 52 ng/mL. The fog improvement was gradual. Not a single moment where it kicked in. More like I looked back at my scores after 6 weeks and realized the bad days had stopped. If you live above 35° latitude and have not tested your D levels you are probably deficient October through March. Magnesium glycinate 400mg before bed. Slutsky et al. published in Neuron 2010 showing magnesium enhances learning and memory. Serum magnesium is a garbage test because it only drops when you are severely depleted. Most people in western countries are sub clinically deficient. The sleep improvement was the first thing I noticed. Deeper sleep within 3 nights. The cognitive effect followed the better sleep by about a week. Do not use magnesium oxide. Bioavailability is terrible. Glycinate or threonate. Tier 3: The stuff people do not want to hear Caffeine elimination. I tapered from 400mg per day to zero over 8 weeks. Days 1 through 3 at each step down were rough. By week 10 at zero caffeine my baseline cognitive scores were higher than my best caffeinated scores. Caffeine does not add energy. It blocks adenosine receptors. Your brain compensates by building more receptors. Now you need caffeine to reach the baseline you would have had without it. I was borrowing from tomorrow every single day for 12 years. 30 minutes of cardio. Not negotiable. Not replaceable with supplements. A single session increases BDNF by 200 to 300%. One session. BDNF is the protein that drives neuroplasticity and repair. A year of regular walking increased hippocampal volume by 2% in clinical trials. That is 1 to 2 years of age related brain shrinkage reversed. Nothing in a capsule does this. Nothing. Cutting alcohol entirely. Not reducing. Cutting. A 2017 BMJ longitudinal study followed 550 people for 30 years. Even "moderate" drinkers at 14 to 21 units per week had significantly increased hippocampal atrophy. Ebrahim et al. showed alcohol destroys deep sleep architecture at any dose. I wore a sleep tracker. Zero deep sleep on drinking nights versus 80 to 90 minutes without. That was enough data. I stopped. Tier 4: The testing that found the actual root cause Full panel bloodwork. Not a CBC. Not a basic metabolic. This is what I asked for specifically: ferritin (not just hemoglobin), B12, folate, 25-OH vitamin D, RBC magnesium, TSH plus free T4 plus TPO antibodies, fasting insulin, HbA1c, CRP. Two things came back off that my DR never would have caught. The ferritin at 22 and the vitamin D at 19. Both technically in range. Both functionally impairing my brain. What did not work: Lion's mane. Took it for 8 weeks. No measurable change on cognitive testing. Maybe it works for some people. Did nothing for me. Alpha GPC. Same. 8 weeks. Nothing on testing. Noopept. Slight subjective feeling of clarity. Nothing on objective testing. Stopped. Modafinil. Worked acutely. Tolerance built within 2 weeks. Sleep quality tanked. Net negative after a month. The takeaway nobody wants to accept: The boring stuff works. The exciting stuff mostly does not. Fixing your air, water, iron, vitamin D, magnesium, sleep, movement, and removing alcohol and excess caffeine will do more for your cognition than every nootropic stack on this sub combined. I know because I tested both. One at a time. With a cognitive testing baseline. The supplements are a rounding error on top of the fundamentals. Fix the fundamentals first or you are optimizing a system that is broken at the foundation. Studies referenced: Allen JG et al. CO2 and cognitive function scores. Environ Health Perspect. 2016. DOI: 10.1289/ehp.1510037 Armstrong LE et al. Mild dehydration affects mood in healthy young women. J Nutr. 2012. DOI: 10.3945/jn.111.142000 Ward AF et al. Brain Drain: smartphone presence reduces cognitive capacity. JACR. 2017. DOI: 10.1086/691462 - Soppi ET. Iron deficiency without anemia — a clinical challenge. Clin Case Rep. 2018;6(6):1082-1086. DOI: 10.1002/ccr3.1529 Slutsky I et al. Enhancement of learning and memory by elevating brain magnesium. Neuron. 2010. DOI: 10.1016/j.neuron.2009.12.026 Topiwala A et al. Moderate alcohol consumption as risk factor for adverse brain outcomes. BMJ. 2017. DOI: 10.1136/bmj.j2353 Ebrahim IO et al. Alcohol and sleep. Alcohol Clin Exp Res. 2013. DOI: 10.1111/acer.12006 Feel free to follow on r/whatisbrainfog where I will be releasing a free website dedicated to my findings over the last 10 years. submitted by /u/Sureokgo to r/Biohackers [link] [comments]

I am trying to get the most out of my Vyvanse before crashing. As well as mitigating some of the crashing side effects (hitting the wall, exhaustion,POTS symptoms, including shortness of breath, and major IRRITABILITY). When the Vyvanse works, I usually get a good 3+ hours out of it and they are the most productive of my day. Would love to find a way to extend efficacy and reduce side effects. I have read that the supplements above can be helpful in conjunction with Vyvanse. Can anyone advise best times to take supplements and if there are any other others you would include or omit? Thank you!! submitted by /u/Personal-Winter-8111 to r/VyvanseADHD [link] [comments]